TOP GUIDELINES OF PKRRATING

3B). R526 in the loop among αJ and αI anchors the C-terminal percentage of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the primary chain carbonyl of R413. The tip on the activation segment is stabilized by a hydrogen bond amongst Y454 and E480 from αF. from the